U.S. Route 441 (US 441) is a north–south United States Highway that runs from Miami, Florida to Rocky Top, Tennessee.

US 23/US 441 turn east, briefly overlapping US 64 southeast of Franklin before separating from the route and continuing to the northeast through the Cowee Mountains.

After passing Dillsboro, US 23/US 441 intersect US 74 (Great Smoky Mountains Expressway); US 23 splits east towards Waynesville, while US 441 joins US 74 westbound towards Bryson City.

After traversing 7 miles (11 km) along the northern banks of the Tuckasegee River, US 441 splits from US 74 and continues north into the Qualla Boundary, along Beloved Man Dr Jerry Wolfe Highway.

[2][3][4] In Cherokee, US 441 shares a short one-half-mile (0.80 km) concurrency with US 19, then continues north along the west bank of the Oconaluftee River.

After entering the Great Smoky Mountains National Park, US 441 connects to the southern terminus of the Blue Ridge Parkway.

Corridor A connects Interstate 285 (I-285) in Sandy Springs, Georgia to I-40 near Clyde, North Carolina; it overlaps twenty miles (32 km) of US 441.

ADHS provides additional funds, as authorized by the United States Congress, which have enabled US 441 to benefit from the successive improvements along its routing in both corridors.

US 441 then replaced NC 107 from US 19A through Cherokee and the Great Smoky Mountains National Park to the Tennessee state line where it continued towards Gatlinburg.