U.S. Route 49W (US 49W) is an 89.3-mile-long (143.7 km) U.S. Highway in the Delta region of Mississippi, passing through Yazoo, Humphreys, Sunflower, and Tallahatchie counties.

US 49W/MS 3 now cross over the Will M. Whittington Auxiliary Channel and Lake Atchaflya before passing through Silver City and having an intersection with MS 149.

US 49W/MS 3 continue northwest to pass through Isola, where it has an intersection with unsigned MS 806 (Belzoni Street) and crosses over Lake Dawson, before entering Sunflower County.

The highway passes northeast through rural areas for several miles before entering Tutwiler and coming to an end at a Y-Intersection between US 49 and US 49E, with MS 3 continuing north along US 49.

This had the effect of lengthening US 49, shortening US 49W, and allowing trucks to follow US 49W without detouring around the middle of Yazoo City.