The two highways continue north and pass businesses as a three-lane road with a center left-turn lane a short distance to the west of Kansas City Southern Railway's Gulfport Branch line.

The tracks head further from the road as it continues through woods and development before MS 149 passes to the west of industry and comes to its northern end at another intersection with US 49 north of Wiggins.

The highway runs northwest through wooded neighborhoods before it passes businesses and parallels Canadian National Railway's Beaumont Subdivision line along Main Street.

MS 149 turns west-northwest away from the tracks and gains median parking spaces as it runs through the downtown area of Mount Olive.

MS 149 leaves Mount Olive and heads northwest on two-lane undivided Old Highway 49 North through wooded areas with some fields and homes, ending at another intersection with US 49.

The two highways head north and pass under Canadian National Railway's Beaumont Subdivision line before MS 28 splits to the east.

MS 149 turns northwest and runs through commercial areas parallel to the railroad tracks, passing to the south of Magee General Hospital.

The highway leaves Magee and continues west through rural areas of homes before it reaches an interchange with US 49 and crosses MS 545 a short distance later.

MS 149 heads northwest through wooded areas with some homes, passing to the northeast of the Boswell Regional Center mental hospital in the community of Sanatorium.

The highway continues west through forests before it enters Mendenhall and passes through residential and commercial areas a short distance to the north of Canadian National Railway's Beaumont Subdivision line.

The road runs past homes and businesses before it reaches an interchange with MS 3 at the western edge of Yazoo City.

Past this interchange, the highway becomes unnumbered and crosses the Yazoo River before heading through a mix of farmland and woodland.

MS 16/MS 149 crosses Broad Lake and continues through rural land, turning northwest and entering Humphreys County.

The road passes to the east of the residential town of Louise before it comes to an intersection with the eastern terminus of the western segment of MS 14.