Will Taylor Bridge to cross the Holston River and meet the eastern end of SR 168 (Governor John Sevier Highway).

The U.S. Highway continues through Alpha (which has been annexed by the city of Morristown), the site of several industrial parks, the National Weather Service forecast office for East Tennessee, Southwest Virginia and Western North Carolina, the Morristown Regional Airport, and the highway's southern intersection with SR 342 and the northern terminus of SR 160 (Air Park Boulevard).

US 11E intersects SR 343 (Cumberland Street) and passes College Square Mall before reaching a partial cloverleaf interchange with US 25E (Davy Crockett Parkway).

On westside of the town, US 11E has a partial cloverleaf interchange with Blue Springs Parkway, which heads east as US 11E Business and SR 70 (Summer Street).

SR 70 joins the U.S. Highway for a short distance before heading north as Lonesome Pine Trail.

After crossing the Knoxville East rail line, the U.S. Highway receives the eastern end of its business route and SR 107 (Tusculum Boulevard).

Highways also pass to the north of David Crockett Birthplace State Park before entering Washington County, where the highways pass along the north edge of Limestone, meet the south end of SR 75 (Opie Arnold Road), and cross Big Limestone Creek.

Just east of the downtown, where US 11E becomes Market Street, US 321 turns south onto State of Franklin Road, a western boulevard bypass of Johnson City that heads north as SR 381.

US 11E passes to the north of Mountain Home, the site of several hospitals, including a VA medical center.

The highways head northeast and cross the Watauga River arm of Boone Lake and enter Sullivan County.

Highways and State Route 381 (SR 381) head north into the independent city of Bristol along Commonwealth Avenue, a four-lane divided highway that intersects Goode Street one block north of the state line; Goode Street carries US 421 and both US 11 Truck and US 19 Truck through the Bristol Commercial Historic District.

[6] When the United States Numbered Highway System was formed by Congress in 1926, SR 34 was designated as US 511, and the route to the west became US 11.

[8][9] Throughout the latter 20th century, most of US 11E was widened to four lanes, and much of the original alignment was relocated in favor of bypasses around business districts of cities and towns.

[10][11] The 11 miles (18 km) stretch between the Greene-Washington County line and Jonesborough was widened between the summer of 1987 and November 1988.

East of where SR 70 splits to the south, the business route enters the town as Summer Street.

The business route and SR 107 turn east onto Tusculum Boulevard, which they follow out of the downtown area and pass through a heavily congested area (they also pass Walters State Community College's Greeneville campus and Greeneville High School) to the business route's eastern terminus at US 11E.