U.S. Route 64 (US 64) is a U.S. Numbered Highway that runs from the Four Corners area in Arizona to the east coast of North Carolina.

In Arizona, the highway starts at U.S. Route 160 (US 160) heading southeast for 4.5 miles (7.2 km) before entering New Mexico near the town of Beclabito.

Through New Mexico the highway passes through Shiprock, Bloomfield, Tierra Amarilla and Taos, sharing a short concurrency with I-25 near Raton, before heading east through Clayton to the Oklahoma state line.

Past the mesa, US 64 passes through sparse ranch land, intersecting BIA 5111 before turning slightly eastward.

The highway then passes through Tres Piedras before crossing via the Rio Grande Gorge Bridge and heading into Taos.

[5][3] On November 11, 1972, US 64 was truncated from Santa Fe to Taos, then extended west through Tres Piedras, Brazos, Monero and Bloomfield to US 550 in Farmington.

US 64 now shared a concurrency with US 84 between Tierra Amarilla and a highway junction 4 miles (6.4 km) east of Monero.