U.S. Route 75 (US-75) is a north–south U.S. Highway stretching from Kittson County, Minnesota to Dallas, Texas.

In Kansas, the highway runs from south to north through the eastern part of the state.

Between Hoyt and Holton, the highway runs along the eastern border of the Potawatomi Indian Reservation.

From January 2004 to August 2009, there was a total of 24 crashes, which included one fatality and fifteen that resulted in injuries.

Smoky Hill LLC from Salina, was the primary contractor on the $2.541 million roundabout project.