U.S. Route 75 (US 75) is a major north–south highway that enters the U.S. state of Oklahoma from Texas concurrent with US 69 crossing the Red River.

Through traffic traveling to Tulsa usually uses US 69 to the Indian Nation Turnpike as a faster route.

Coming out of Okmulgee, US 75 starts to enter a more urban area traveling into Tulsa.

The two highways travel into Downtown Tulsa together, where US 75 splits off with a short overlap with US 64/SH 51.

From here, the highway travels to Kansas, only passing through the major community of Bartlesville.