On the east side of the city, US 82 travels as a surface street along Parkway Drive and it once again merges with US 62 (along with State Highway 114) where it continues eastward through Ralls, where US 62 makes a sharp turn to the north and leaves the route.

US 82 continues eastward across the level plains of the Llano Estacado to Crosbyton and then dips downward as it crosses the White River of Blanco Canyon, where the Texas Department of Transportation maintains the Silver Falls Rest Area with facilities and hiking trails.

After climbing out of Blanco Canyon, US 82 eventually exits the Llano Estacado and enters the rolling plains near Dickens.

After passing around Clarksville and other smaller towns the highway is crossed by Interstate 30 east of New Boston at a partial cloverleaf and continues to run parallel to IH 30 into Arkansas through downtown Texarkana.

[3] The highway was re-routed from Allendale Road to US 281/US 287 through Wichita Falls in 1998 with a bypass built around Holliday in 2005.

Long term planning calls for U.S. 82 to be a four-lane divided highway system the entire length between Wichita Falls and Texarkana as a potential alternate route through north Texas in order to bypass the overcrowded Dallas/Fort Worth Metroplex.

It is being upgraded to a 4 lane divided highway west of Nocona, and a partial bypass is planned to run south of Gainesville.