1JMT7307n/aENSG00000160201n/aQ01081P0DN76n/aNM_001025203NM_001025204NM_006758n/aNP_001020375NP_006749NP_001020374NP_001020375NP_006749n/aSplicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

U2AF1 is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site.

This gene encodes a small (~35 kDa) subunit which plays a critical role in RNA splicing by recognizing and binding to AG nucleotides at the 3’ splice site to facilitate spliceosome assembly.

[6] Alternatively spliced transcript variants encoding different isoforms have been identified [citation needed].

[7] In lung cancers, these mutations affect alternative splicing of several transcripts, including oncogenic ROS1 fusions.