UFC 64: Unstoppable was a mixed martial arts event held by the Ultimate Fighting Championship on Saturday, October 14, 2006.

The event took place at the Mandalay Bay Events Center, on the Las Vegas Strip in Nevada and was broadcast live on pay-per-view in the United States and Canada.

The card centered on a UFC Middleweight Championship defense by Rich Franklin against the highly touted Anderson Silva.

The card also featured a UFC Lightweight Championship bout between The Ultimate Fighter alumnus Kenny Florian and longtime UFC veteran Sean Sherk.

A planned match between Keith Jardine and Mike Nickels was cancelled a day before the event when Nickels reaggravated a previous back injury sustained during training.