[9] A lightweight bout between Roosevelt Roberts and Matt Frevola was previously scheduled to take place at another event earlier in the year.

[13] A light heavyweight bout between Ed Herman and Gerald Meerschaert was previously scheduled for August 1 at UFC Fight Night: Brunson vs.

[17] Herman then suffered another opponent change on September 3, as Allan pulled out due to visa issues and was replaced by Mike Rodríguez.

[18] A lightweight bout between Khama Worthy and Ottman Azaitar was previously scheduled to take place earlier this year at UFC 249.

[23] A flyweight bout between promotional newcomer Tagir Ulanbekov and Bruno Gustavo da Silva was expected to take place at this event.

[24] However, due to travel restrictions related to the COVID-19 pandemic, the pairing was rescheduled and expected to take place four weeks later at UFC Fight Night: Moraes vs.

[30] On September 18, it was announced that Mike Rodríguez will appeal his submission loss against Ed Herman citing a referee error.

Herman immediately dropped and before Rodríguez was able to deliver more strikes, referee Chris Tognoni stepped in and called a pause to the action due to a possible low blow.

Also of note in the appeal, Rodríguez's team alleged that during the finishing sequence Herman illegally had his toes in the fence to sweep into top position and gain more leverage for the hold.