[5] UNC13A plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway.

It plays a role in dendrite formation by melanocytes and in secretory granule priming in insulin secretion.

[7] UNC13A has been shown to interact with: Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis.

This variation of the single nucleotide involving UNC13A has also been implicated in frontotemporal dementia (FTD).

[16] This article incorporates text from the United States National Library of Medicine, which is in the public domain.