It is the capital city's oldest hospital, founded by a bequest from John T. Rex (1771–1839),[1] a local tanner and business owner.

[3] Rex is located just 2 miles from the Lenovo Center, and is the official healthcare provider of the Carolina Hurricanes[4] and NC State Wolfpack.

[5] In addition to the main hospital in Raleigh, Rex Health Care has locations throughout Wake County.

[11] In December 2021, Rex opened a new facility in Holly Springs offering multiple services.

In a study done by an independent company, Axial Exchange, Rex was ranked highest based on readmissions, patient satisfaction, and self care tools and education.