[3] Hillman works with UPMC Cancer Centers Network to translate the latest research advances to clinical application for patients.

[14][15] In November, 2008, UPMC announced a partnership with GE Healthcare to open 25 additional cancer treatment centers across Europe and the Middle East over the next ten years.

[16][17] The UPMC Hillman Cancer Center in the Shadyside neighborhood of Pittsburgh is the flagship facility for the clinical services and research activities.

It is located across Centre Avenue from, and connected via a pedestrian bridge to, UPMC Shadyside hospital, where cancer surgery and Intensity Modulated Radiation Therapy (IMRT) are conducted.

[21] It also includes waiting rooms equipped with televisions and play areas for children and access to a kitchen stocked with beverages and refreshments.

The outpatient clinic, known as The William Cooper Pavilion, honoring the oncologist who led the campaign for philanthropic support of the center, was designed by architectural firm Radelet McCarthy.

The center is dedicated to former Pittsburgh Penguins hockey player Mario Lemieux, who was diagnosed with Hodgkin's lymphoma in 1993 and was cured.