The USCGC Harriet Lane (WSC-141) was a 125-foot patrol boat, commonly known as a "buck-and-a-quarter", 1926–1946.

She was the second ship named for Harriet Lane.

She was based in Boston, Provincetown and Gloucester, Massachusetts.

In 1941, the cutter served in World War II, and after for the Fifth Coast Guard District, home ported in Norfolk, Virginia.

This article about a specific ship or boat of the United States Armed Forces is a stub.