USCGC Reliance (WSC-150) was a 125-foot (38 m) steel-hulled single-screw Active-class patrol boat of the United States Coast Guard.

[1][2] USCGC Reliance (WSC-150) was one of the 35-ship Active class, designed to serve as a "mother ship" in support of Prohibition against bootleggers and smugglers along the coasts.

They were meant to be able to stay at sea for long periods of time in any kinds of weather, and were able to expand berthing space via hammocks if the need arose, such as if a large amount of survivors were on board.

[3] Reliance was operating out of Honolulu, Hawaii at the outbreak of World War II and was subsequently assigned to search and rescue duties at the base in Cordova, Alaska.

A Court Inquiry investigated the sinking found the vessel sank at 1820 on 4 July 1944 in 1,400 fathoms (8,400 ft; 2,600 m) of water, without a cause being identified.

[3] Reliance was returned to the Department of the Treasury on 1 January 1946 and served with the Coast Guard until it was decommissioned on 8 August 1947.