SS Mission San Miguel was a Type T2-SE-A2 tanker built for the United States Maritime Commission during World War II.

Mission San Miguel was laid down 11 August 1943 under a Maritime Commission contract by Marine Ship Corporation, Sausalito, California; launched 31 October 1943; sponsored by Mrs. John W. Hardie; and delivered 19 February 1944.

Chartered to Pacific Tankers, Inc. for operations, she spent the remainder of the war carrying fuel to Allied forces overseas.

Transferred to the operational control of the newly created Military Sea Transportation Service on 1 October 1949, she was redesignated USNS Mission San Miguel (T-AO-129).

Reactivated and placed in service with MSTS 1 November 1956, she served until 8 October 1957 when she ran aground on Maro Reef in the Hawaiian Islands while running at full speed and in ballast.