USS Betty M. II (SP-623) was a United States Navy patrol vessel in commission from 1917 to 1918.

Betty M. II was built as a private motorboat of the same name by the Church Boat Company at Sibley, Michigan, in 1916.

In 1917, the U.S. Navy acquired her under a free lease from her owner, Charles W. Kotcher of Detroit, Michigan, for use as a section patrol boat during World War I.

After towing the patrol boat USS Welcome (SP-1175) to the American Boat Company dock at Detroit, Betty M. II was hauled out of the water for the winter on 26 November 1917 and inactivated prior to the seasonal icing over of the Great Lakes.

On 25 November 1918, Betty M. II was hauled out of the water for the season and decommissioned.