Cabezon departed New London, Connecticut, 19 February 1945 for Key West, Florida, where she underwent 3 weeks of training and providing services for the Fleet Sound School.

From 25 May to 11 July 1945 Cabezon conducted her first war patrol in the Sea of Okhotsk, sinking a 2,631-ton Japanese cargo vessel on 19 June.

She refitted at Midway until 4 August, then departed for Saipan to serve as target ship for surface force training exercises.

On 6 February 1946 Cabezon arrived at San Diego, operating from that port until her base was changed to Pearl Harbor.

She also made two cruises to the Far East (18 March – 29 July 1950 and 21 April – 16 October 1952), the second of which included a reconnaissance patrol in the vicinity of La Perouse Strait, between Hokkaidō, Japan, and Sakhalin, U.S.S.R. Cabezon sailed for Mare Island 21 April 1953 to start inactivation and was placed out of commission in reserve there 24 October 1953 and laid up in the Pacific Reserve Fleet.