On 28 April, this force sortied for air attacks on Japanese strongholds at Truk, Woleai, Satawan, and Ponape, during which Cassin Young operated as a picket ship, assigned to warn her group of possible enemy counterattack.

She returned to Majuro, and then Pearl Harbor for further training before reporting to Eniwetok on 11 June to join the screen of escort carriers assigned to covering duty in the invasion of Saipan four days later.

As the battle for Saipan raged ashore, escort carriers of Cassin Young's group launched attacks on the island, as well as sorties to neutralize enemy air fields on Tinian, Rota, and Guam.

Similar operations supporting the subsequent assaults on Tinian and Guam claimed the services of Cassin Young until 13 August, when she returned to Eniwetok to replenish.

Between 29 August and 2 October 1944, Cassin Young guarded the carriers of Task Group 38.3 as strikes were flown from their decks to hit targets on Palau, Mindanao, and Luzon in support of the assault on the Palaus, stepping-stone to the Philippines.

Only four days after her return from this mission to Ulithi, Cassin Young sailed on 6 October with the same force on duty in the accelerated schedule for the Philippines assault.

On 14 October, the cruiser Reno was struck by a kamikaze, which wounded five of Cassin Young's men with machine gun fire.

On 18 October 1944, TF 38 took position east of Luzon to launch strikes immobilizing enemy air fields there in preparation for the assault on Leyte two days later.

This developed on 25 October into the Battle off Cape Engaño, a series of air strikes in which four Japanese carriers and a destroyer were sunk.

After screening heavy ships in the massive pre-invasion bombardment, Cassin Young moved inshore to support the activities of underwater demolition teams preparing the beaches.

Cassin Young's accurate gunfire had aided in shooting down five aircraft, but a sixth crashed high-up into her foremast, exploding in midair only 50 feet (15 m) from the ship.

The next day, she was struck for the second time, when a low-flying aircraft hit her starboard side, striking her fire control room.

A tremendous explosion amidships was followed by fire, but the crew managed to restore power to one engine, get the flames under control, and had the ship underway for the safety of Kerama Retto within 20 minutes.

Her operations from that time until 1960 included training exercises in the Caribbean and off the eastern seaboard as well as tours of duty in the Mediterranean in 1956, winter 1956–57, and 1959, and a round of visits to ports of northern Europe in 1958.