From 5 June 1900 to 18 October 1900 Don Juan de Austria was anchored off Canton, China, to protect American interests during the Boxer Rebellion.

After repairs at Yokohama, Japan, from 27 April 1903 to 1 June 1903, Don Juan de Austria cruised along the Chinese coast for maneuvers with the U.S. fleet, an indication of intensified American interest in the Far East after the acquisition of Pacific island territories.

She departed Hong Kong 16 December 1903 for the United States, sailing by way of Singapore, Ceylon, India, the Suez Canal, and Mediterranean ports to arrive at Portsmouth Navy Yard, Kittery, Maine, on 21 April 1904.

Joining the Third Squadron, Atlantic Fleet, Don Juan de Austria sailed from Norfolk, Virginia, on 28 February 1906 to patrol off the Dominican Republic to protect American interests there.

On 3 April 1919, Don Juan de Austria arrived at Boston, Massachusetts, to join the special escort for the transports returning members of the 26th Division, U.S. Army, from Europe.