USS General Burnside was a steamship acquired by the Union Navy during the American Civil War.

General Burnside, built in 1862 at Wilmington, Delaware, was sold to the U.S. War Department in 1863 and chartered by the Union Navy.

General Burnside became flagship of the upper Tennessee River Fleet, Mississippi Squadron, 15 October 1864.

The gunboat continued river patrol until 1 June 1865 when she was returned to the War Department at Bridgeport, Alabama.

This article incorporates text from the public domain Dictionary of American Naval Fighting Ships.