USS Henry Andrew was a steamer acquired by the Union Navy during the American Civil War.

Henry Andrew was originally built in 1847 at New York City as a sailing brig, and converted to steam in 1859.

Being of light draft, Henry Andrew was especially valuable in stopping blockade runners and gaining intelligence in the shallow rivers and sounds of the coast.

[1] Subsequently, the ship was active in the blockade off Mosquito Inlet, Stono River, and other points on the coast until sent to Winyah Bay, South Carolina, where she arrived on 21 June.

Returning on 3 July, Henry Andrew resumed blockading duties off Stono River until ordered to New York in August for extensive repairs.