The second USS Tigress was a steamer chartered by the United States Navy at the beginning of the American Civil War.

After her conversion for Navy service was completed, Tigress received orders to patrol the Potomac River.

She joined Captain Thomas T. Craven′s Potomac River Flotilla on 26 August 1861 and operated largely in patrol activities.

On two occasions in early September 1861, she carried captured runaway slaves to Craven′s flagship, the gunboat USS Resolute.

On the evening of 10 September 1862, while Tigress was on patrol off Indian Head, Maryland, the steamer State of Maine collided with and sank her.