During the subsequent operations with the 6th Fleet in this area, Holder visited Egypt and Saudi Arabia, arriving Newport on 22 March 1947.

In June–July 1949 Holder took part in a midshipman training cruise to northern Europe and upon her return moved her home port from Newport to Norfolk.

Her classification was changed to DDE-819 on 4 March 1950, but she continued to alternate cruises to Europe and the Mediterranean with periods of training and upkeep out of Norfolk and the Caribbean.

The veteran destroyer, reclassified DD-819 again on 7 August 1962, took part in another graphic demonstration of the importance of sea power, this time in the Western Hemisphere.

New weapons, including ASROC and QH-50 DASH, and a helicopter hangar and flight deck increased the ship's anti-submarine capability.

Between 26 April and 17 May, Holder patrolled the Dominican Republic's coast during the struggle to prevent a Communist takeover of that island nation.