She arrived in Constantinople on 22 October and was constantly used to carry supplies, medical aid, refugees, and relief officials between ports of the Black Sea and the Eastern Mediterranean.

She departed New York on 13 February 1925 for a fleet training cruise to San Diego, California, and from there she sailed to Pearl Harbor and returned on 17 July.

She got underway from San Diego on 27 April 1936 for fleet exercises in the Caribbean before entering the New York Navy Yard to prepare for special service.

On 30 August, en route to Bilbao, she had to open fire three times to drive off a tri-motored monoplane dropping bombs within a hundred yards of the destroyer.

This special squadron, initially comprising Raleigh, Kane, Hatfield and USCGC Cayuga, saved hundreds of American and other nationals from the dangers of the war in Spain.

She overhauled in the Puget Sound Naval Shipyard from 4 January to 3 March 1941, she was based in Seattle for patrols north to Alaska, and along the United States West Coast.

She continued to patrol and escort duty in Alaskan and Aleutian sectors until February 1942, then was converted to a high-speed transport by Todd's Dry Docks, Seattle, Washington, and reclassified APD-18 on 25 March 1943.

[1] During the ground fighting on Attu, Kane served as evacuation hospital transport and shuttled medical supplies between Holtz and Massacre Bay.

Kane remained on duty between Alaskan and Aleutian ports until 20 November 1943, then steamed south for an overhaul in the Mare Island Navy Yard until 7 January 1944.

She sailed on 25 February to help screen amphibious landing ships for the invasion of Milne Bay, New Guinea, then entered Seeadler Harbor, Manus, as the 7th Cavalry Regiment took the remaining strong point in the Admiralty Islands.

The high-speed transport landed men of the 163d Infantry at Aitape on 22 April 1944 and bombarded enemy positions before withdrawing to shell Ali Island.

After the fast carriers of the 5th Fleet destroyed Japan's carrier-based airpower in the Battle of the Philippine Sea, the transport supported Underwater Demolition Team 4 in operations off Saipan.

Kane departed San Diego on 20 April 1945 to train Underwater Demolition Team 24 in Hawaiian waters until 4 May, then arrived off Kerama Retto on 12 June.

She became a unit of the Philippine Sea Frontier on 4 July and patrolled the shipping lanes leading eastward guarding against submarines until the end of hostilities.