USS Little (DD-803), a Fletcher-class destroyer, was the second ship of the United States Navy to be named for Captain George Little (1754–1809).

Little was laid down by Seattle-Tacoma Shipbuilding Corp., Seattle, Wash., 13 September 1943; launched 22 May 1944, sponsored by Mrs. Russell F. O'Hara; and commissioned 19 August 1944.

After training off the West Coast, Little departed Seattle 11 November 1944 to escort a convoy to Pearl Harbor.

Little sailed for Okinawa 27 March assigned to the demonstration group charged with feigning landings opposite the actual assault beaches.

Within four minutes three more enemy kamikazes had hit her, breaking her keel, demolishing the amidship section, and opening all three after machinery spaces.