On the night of 4 September 1942 Little challenged a vastly superior Imperial Japanese Navy force then engaged in shelling American-held positions on Guadalcanal.

First came the clearing of mines from Japanese harbors, then a series of shuttle runs between Okinawa and Shanghai, and finally her return to San Francisco on 28 March 1946 with a group of Marines embarked at Tsingtao, China.

Planes from these carriers played an important part in successful evacuations in November and December of United Nations troops from North Korea in the wake of Chinese Communist intervention.

As on her two succeeding tours she also took part both in the naval siege of Wonsan, Korea, and the preventive patrolling of the Formosa Straits before returning home on 2 July 1951.

Refurbished on 23 July 1962, Lofberg steamed forth to undergo a refresher training cruise and exercises designed to teach the effective use of her new helicopter flight deck.

During 1964-1965 cruise Lofberg's division surfaced two Russian submarines and escorted them from South China Sea...Lofberg was part of the Destroyer Division and Carrier Hancock that established Station Yankee in Gulf of Tonkin... Lofberg cruised off coast of North Vietnam using ECM to do target designation for Carrier Based Bombers and B52's out of Guam awarded two Armed Forces Expeditionary Medals one for 30 days at Station Yankee and one for 90 days off coast of North Vietnam also awarded ASWA "A" for proven excellence in antisubmarine warfare....because the bombing from Operation Rolling Thunder caused 140,000 civilian casualties President Johnson made Operation secret and no medals were awardedETN-2 ECM midwatch in Lofberg CIC Once home from the newest war zone, Lofberg underwent a three-month drydock period and in October commenced tactical exercises in the southern California operation area.

The destroyer reentered the South China Sea 26 April 1966, and during the next six months served first on Yankee Station and then provided gunfire support to allied forces ashore.