In August 1943 Macomb returned from a tour of duty with the British Home Fleet and operated again off the Atlantic seaboard with only one break until mid-1944.

On this one exception she made an uneventful cruise to the Azores; Freetown, Sierra Leone; Dakar, Senegal; and Bermuda before returning to Boston in late December.

On 18 May, just before midnight, she commenced a 72-hour submarine chase that ended when U-616 was blasted to the surface by Macomb's depth charges and then sunk by her guns.

In mid-August 1944 she took part in the invasion of southern France, returning to antisubmarine patrol afterward Macomb arrived at Charleston Navy Yard 9 November for conversion to a destroyer minesweeper.

On 29 August, Just ahead of the battleships Missouri and Iowa, she dropped anchor in Tokyo Bay, where she was witness to the formal surrender.

Leaving Tokyo Bay on 4 September 1945, she commenced sweeping mines in the Japanese area, off Okinawa, near the entrance to the Yellow Sea, and in the Chosen Straits.

In June, 1948, Charleston, South Carolina, become her home port, and until September 1949, Macomb went on patrols and took part in exercises along the eastern coasts of the United States and Canada and in the Caribbean.

During each cruise Macomb participated in the 6th Fleet exercises and operations, lending support to American diplomatic efforts at settling the unstable political situations then existent in many of the Mediterranean countries.

She was then sold to the Republic of China on 6 August 1970, to replace the former Gleaves-class destroyer Rodman (which had been damaged after running aground) as ROCS Hsien Yang (DD-16).