USS Mosley (DE 321) was an Edsall-class destroyer escort built for the U.S. Navy during World War II.

In January 1942, he flew with his squadron to Darwin, Australia, to support the Allied attempt to halt the Japanese advance through Southeast Asia.

Based on USS William B. Preston, he flew patrols north of Australia into the Java Sea and surrounding waters plotting the movements of the Japanese.

With Lt. Thomas H. Moorer as pilot, the patrol plane spotted a merchant ship off Melville Island, Australia, and turned to investigate.

About 09:20, nine Japanese fighters, part of a 70 plane force en route to bomb Darwin, Australia, jumped the PBY.

Survivors, including Mosley, made Bathurst Island in two lifeboats about midnight and an RAAF patrol plane spotted them on the 21st.

Between 31 January and 18 March 1944, she screened a UGS GUS convoy to north Africa and back; then, following anti-submarine warfare (ASW) training off Block Island, she reached Norfolk 1 April for further escort duty.

The first attack blew the troop-loaded merchantman SS Paul Hamilton out of the water, killing 580 men; the next wave hit two more merchant ships; and the final strike sank screening escort USS Lansdale with a single torpedo which split open the unlucky destroyer.

Designated Task Group 22.14, Mosley and sister escorts, Pride, Menges, and Lowe trained off Block Island before steaming to Casco Bay on 4 March.

On 18 March in waters west of treacherous Sable Island, day-long hedgehog and depth charge attacks brought "air bubbles, wreckage, and large quantities of oil" to the surface.

A violent underwater explosion at 1622 marked the end of U-866, and the hunter killer group returned to Casco Bay on 20 March.

Mosley resumed ASW patrols in the Gulf of Maine on 24 March; then, until 4 April, she searched the stormy North Atlantic south and west of Flemish Cap.

On 10 April, TG 22.14 rendezvoused at sea with a hunter-killer group built around USS Mission Bay and began barrier patrols along the 30th meridian north of latitude 48°30'.

At about the same time as Mosley first made contact, escorts Carter and Neal A. Scott attacked and sank U-518 some 100 miles southward along the barrier.

She was patrolling the North Atlantic about 300 miles south of Cape Race, Newfoundland, as President Truman announced the German surrender on 8 May.