Nebraska shares her nickname, "Big Red", with the University of Nebraska-Lincoln's athletic teams.

The contract to build Nebraska was awarded on 26 May 1987 to the Electric Boat Division of the General Dynamics Corporation at Groton, Connecticut.

In 2013 Nebraska transferred to Submarine Squadron 19 to conduct an Engineering Refueling Overhaul.

In the military hard science fiction Looking Glass series by John Ringo and Travis S. Taylor, Nebraska is converted into the first human interstellar spaceship and renamed Vorpal Blade.

[9] The boat is the main setting for the majority of the second, third, and fourth books in the series, Vorpal Blade, Manxome Foe, and Claws That Catch.