[a] The contract to build Wyoming was awarded to the Electric Boat Division of the General Dynamics Corporation in Groton, Connecticut, on 18 October 1989 and her keel was laid down there on 8 August 1991.

On 6 June 2012, Wyoming participated in a historic medevac exercise with a Bell Boeing V-22 Osprey making a 12,000 nautical mile flight to collect a stretcher from the submarine.

[7] On 7 January 2018, she arrived at Norfolk Naval Shipyard to begin a 27-month overhaul to include midlife refueling, technological upgrades, and new berthing spaces for enlisted women.

During patrols from August to November 2013 and March to June 2014, four women were secretly recorded in the shower changing room, including midshipmen and officers assigned to the boat.

[13] On 24 March 2022 Wyoming became the first ballistic submarine in US Navy history to complete a deterrent patrol with enlisted females as part of the crew.