USS Patroon was a screw steamer acquired by the United States Navy during the American Civil War.

Patroon, a wooden screw steamer built at Philadelphia, Pennsylvania, in 1859, was purchased from R. T. Loper by the U.S. Navy 28 October 1861 at Trenton, New Jersey.

Assigned to the South Atlantic Blockading Squadron, Patroon was stationed off the coast of Florida off the St. Johns River early in May 1862.

The highlight of her U.S. Navy service came on 11 September 1862, when, with the gunboat USS Uncas, she dueled with Confederate artillery batteries at St. John's Bluff, Florida.

Throughout her U.S. Navy career, leaks and a variety of other problems limited Patroon's effectiveness, and she was soon ordered north.