Following her initial shakedown off the coast of New England and the Maritime Provinces, Quick departed New York, 6 September 1942, for the Caribbean Sea and the Gulf of Mexico.

Just before midnight on 7 November, she arrived off the coast of Safi, Morocco, and took up station in the transport area for the Southern Attack Group of Operation TORCH the invasion of North Africa.

The war in the Pacific Ocean continued, however, and, as Allied forces pushed closer to the Japanese home islands, their need for minesweepers increased, doubly so with the toll among that type in the Ryukyus.

Emerging from conversion on 2 August as DMS-32 (effective 23 June 1945), she sailed for the west coast, arriving at San Diego after the cessation of Pacific hostilities.

Reclassified DD-490 on 15 July 1955, Quick was stricken from the Naval Vessel Register on 15 January 1972, sold on 27 August 1973 and broken up for scrap.