With one exception, a deployment to Adak, Alaska, in support of the Attu and Kiska operations, Shasta's activities centered around the campaigns in the western Pacific.
Later, while re-supplying the warships supporting the assault on Iwo Jima, she unloaded ammunition while under attack by Japanese shore batteries.
Her most harrowing experience occurred on 5 June when she was battered by the force fourteen winds of a typhoon off the southeastern coast of Okinawa.
At the completion of modernization overhaul at Norfolk and underway replenishment training off Newport, R.I., Shasta sailed on 7 January for her first Mediterranean deployment.
She acted as a target ship for nuclear submarines, tested instruments on a dummy Polaris missile attached to her keel, and took part in NATO exercises.
She transited the Panama Canal on 20 September, called briefly at Pearl Harbor, and arrived at Subic Bay in the Philippines on 26 October.
En route to Rota, Spain, and assignment with the 6th Fleet, she was diverted to assist in the unsuccessful search for nuclear submarine, USS Scorpion (SSN-589), which was lost with all hands off the Azores.
Main engine difficulties caused Shasta to cut short her projected six-month deployment and return to Norfolk for major repairs.