USS Spitfire was a bomb ketch converted from a sloop that served the U.S. Navy during the republic's early years.

She carried ammunition for the U.S. Navy warships in the Mediterranean in their battles with the Barbary pirates, and was later involved in the Little Belt affair prior to the War of 1812.

Commanded by Midshipman Daniel McNeill, Jr., Spitfire sailed for the Mediterranean on 23 June 1805 and reached Gibraltar on 1 August.

The ship was reactivated in July 1807 under the command of Midshipman F. Cornelius de Kroff but remained at Norfolk until laid up again in December.

Guerriere impressed the apprentice sailing master of Spitfire, John Diggio, a citizen of Maine.