She returned to Boston on 19 March 1944 for availability before moving to Norfolk, Virginia, to conduct high-speed, over-the-stern fueling exercises with Aucilla under the auspices of the Bureau of Ships.

From Hampton Roads, the destroyer moved to Key West, Florida, at the end of the first week in April to conduct antisubmarine warfare (ASW) tests on a new type of sound gear.

On 7 and 8 June, she conducted shore bombardments, destroying blockhouses and machine-gun positions as well as helping to repulse a counterattack mounted by German armored units.

Four days later, the ship departed Norfolk in the screen of the aircraft carrier Ticonderoga, bound ultimately for the western Pacific.

The troops of the United States Army's 77th Infantry Division stormed ashore unopposed on 7 December, but the Japanese mounted heavy kamikaze attacks on the supporting ships in an attempt to foil the assault.

The next day, en route back to San Pedro Bay, she helped to splash an attacking enemy aircraft.

En route, she drove off by antiaircraft fire several planes which approached her and arrived safely in San Pedro Bay on 18 December 1944.

American minesweepers moved into the gulf on 6 January, and Walke steamed in with them to provide covering fire and antiaircraft defense.

The third plane pressed home his combination strafing run-suicide attack and, though hit several times, managed to crash into Walke's bridge on the port side and burst into flames.

The 250-pound (110 kg) bomb the plane carried did not explode but passed completely through the ship in the vicinity of the combat information center.

Their concentrated fire saved the ship from a second crash when the plane burst into flames and splashed into the sea close aboard.

John F. McGillis took command of the ship and set a course—via Pearl Harbor, Eniwetok, and Ulithi— for Okinawa where, on 10 May, she joined the campaign to capture that island.

The following day, she departed the Ryukyus in the screen of a task unit, bound for Leyte, and underwent an availability at San Pedro Bay from 28 July to 14 August.

Walke entered San Diego on 22 August and then moved to the Mare Island Naval Shipyard for three months of repairs.

On 6 January 1947, Walke departed San Diego for Pearl Harbor whence she operated with the aircraft carrier Tarawa, and later with Shangri-La, on special duty under the auspices of the Commander, Naval Air Force Pacific Fleet.

Following a little over three years in the San Diego Group, Pacific Reserve Fleet, Walke was recommissioned on 5 October 1950 with CDR Marshall F. Thompson in command.

After shakedown training along the west coast, the destroyer departed San Diego on 2 January 1951 and set a course for the Far East and service in the six-month-old Korean War.

In addition to providing antisubmarine protection for the carriers of TF 77, she moved close to the Korean coast to contribute to the blockades of various enemy ports, such as Yondae Gap, Wonsan, Songjin, Chongjin, and Chuminjin as well as various other rail and road locations.

On 12 June, while steaming some 60 miles off the Korean coast with TF 77, Walke struck either a floating mine, or was hit by a torpedo, which severely damaged her hull on the port side, killing 26 men and wounded another 35 sailors.

Walke returned to the Korean combat zone in June 1952 and resumed screening duty with TF 77 punctuated by shore bombardment missions.

That combat cruise lasted until January 1953, when she arrived in Long Beach, California, and took up normal west coast operations.

In that interval, she made six deployments to the Orient, on each occasion operating as a unit of the 7th Fleet and usually as a part of the ASW screen of the fast carriers of TF 77.

The ship made frequent visits to such ports as Sasebo and Yokosuka in Japan, Hong Kong, and Subic Bay in the Philippines.

On her return voyage from the 1956 to 1957 western Pacific cruise, Walke visited Brisbane, Australia, before steaming back to Long Beach on 28 April 1957.

When not deployed to the Far East, the destroyer operated along the west coast conducting ASW and gunnery training and independent ship's exercises.

(92 23 "The Case of the Slandered Submarine" Arthur Marks Samuel Newman N/A 14 May 1960 171-107 Cast: Hugh Marlowe (Commander James Page), Jack Ging (Seaman Robert Chapman), Robert H. Harris (Gordon Russell), Edward Platt (Commander Driscoll)[7]: 125–126 ) // (Wikipedia list of Perry Mason episodes) In 1964 and 1965, however, events in South Vietnam conspired to make Walke's final four deployments to the Far East combat tours.

The destroyer's damage control efforts succeeded in putting the blaze out; but, while the ship was being towed back into Long Beach on 10 June, her towline parted, and she ran aground.

That assignment lasted until 11 December at which time she moved inshore to provide gunfire support for troops operating ashore in the I Corps combat zone.

At the conclusion of that repair period in September, she conducted shakedown training and then began normal west coast operations.

On 30 November 1970, she was decommissioned at the Puget Sound Naval Shipyard and was berthed with the Columbia River Group, Pacific Reserve Fleet, until 1974.