During the First World War, she was part of the Battleship Division Nine, which was attached to the British Grand Fleet as the 6th Battle Squadron.

She served in both the Atlantic and Pacific Fleets throughout the 1920s, and in 1931–1932, she was converted into a training ship according to the terms of the London Naval Treaty of 1930.

She continued in this duty until 1947, when she was decommissioned on 1 August and subsequently sold for scrap; she was broken up in New York starting in December 1947.

The ship was powered by four-shaft Parsons steam turbines and twelve coal-fired Babcock & Wilcox boilers rated at 28,000 shp (21,000 kW), generating a top speed of 20.5 kn (38.0 km/h; 23.6 mph).

[2] Wyoming then took part in gunnery drills off the Virginia Capes, and on 18 April, entered drydock at the New York Navy Yard for some repairs, which lasted until 7 May.

[2] Wyoming operated out of the Chesapeake Bay area for the next seven months, training engine-room personnel for the expanding American fleet.

On 25 November, Battleship Division 9 (BatDiv 9), which at that time comprised Wyoming, New York, Delaware, and Florida, departed the US, bound for Britain.

[2] On 6 February, Wyoming and the other American battleships undertook their first wartime operation, to escort a convoy to Stavanger, Norway, in company with eight British destroyers.

[2] During the operation, jumpy crewmen again incorrectly reported U-boat sightings, and Wyoming opened fire on the supposed targets.

[2][8] On 12 December, Wyoming, now the flagship of Rear Admiral William Sims, the new BatDiv 9 commander, left Britain for France.

There, she rendezvoused off Brest, France, with George Washington, which was carrying President Woodrow Wilson to the peace negotiations in Paris.

On 12 May, she left port to help guide a group of Navy Curtiss NC flying boats as they made the first aerial transatlantic crossing.

After finishing the cruise, Wyoming entered dry dock at the Norfolk Navy Yard on 1 July for a modernization for service in the Pacific.

[2] On 2 August, Wyoming was in Balboa in the Canal Zone, where she picked up Rear Admiral Rodman and a commission traveling from Peru back to New York.

Wyoming spent the next three and a half years on the normal routine of winter fleet exercises off Cuba, followed by summer maneuvers off the east coast of the US.

Throughout the period, she served as the flagship of Vice Admirals John McDonald, Newton McCully, and Josiah McKean in the Scouting Fleet.

In the summer of 1924, she conducted a midshipman training cruise to Europe, and stopped in Torbay, Great Britain, Rotterdam in the Netherlands, Gibraltar, and the Azores.

She was attacked by "Black" aircraft, but the umpires judged Wyoming's anti-aircraft fire and the escort fighters provided by Langley to have effectively defended the fleet.

She visited San Diego on 18–22 June, and then returned to the east coast via the Panama Canal, arriving in New York on 17 July.

A cruise to Cuba and Haiti followed, after which Wyoming returned to the New York Navy Yard for an overhaul that lasted from 23 November to 26 January 1926.

Her old coal-fired boilers were replaced with new oil-fired models and anti-torpedo bulges were added to improve her resistance to underwater damage.

She was back in Philadelphia on 7 December, and two days later, she returned to her post as the flagship of the Scouting Fleet, flying the flag of Vice Admiral Ashley Robertson.

[2] Wyoming spent the next four years conducting training cruises for midshipmen and NROTC cadets to various destinations, including European ports, the Caribbean, and the Gulf of Mexico.

Wyoming immediately steamed to San Pedro and transferred the wounded Marines to the hospital ship Relief.

She reached Norfolk on 23 March, where she served as the temporary flagship for Rear Admiral Wilson Brown, the commander of the Training Squadron, from 15 April to 3 June.

[2] After the outbreak of World War II in Europe in September 1939, Wyoming was assigned to a naval reserve force in the Atlantic, alongside the battleships New York, Arkansas, and Texas and the aircraft carrier Ranger.

[2] Early in the war, the Navy briefly considered converting Wyoming back to her battleship configuration, but decided against the plan.

[9] New fire control radars were also installed; these modifications allowed Wyoming to train anti-aircraft gunners with the most modern equipment they would use while in combat with the fleet.

[2] Wyoming finished her gunnery training duties in the Chesapeake area on 30 June 1945, when she left Norfolk for the New York Navy Yard, for further modifications.

[2] In the summer of 1946, then-Ensign Jimmy Carter, the future President of the United States, came aboard as part of the final crew of the old battleship.