The UVA Wise Cavaliers (formerly Virginia–Wise Cavaliers), nicknamed the "Highland Cavaliers" before 2017, are the athletic teams that represent the University of Virginia's College at Wise, located in Wise, Virginia, in intercollegiate sports as a member of the NCAA Division II ranks, primarily competing in the South Atlantic Conference (SAC) since the 2019–20 academic year.

[1] The Cavaliers previously competed in the D-II Mountain East Conference (MEC) from 2013–14 to 2018–19.

UVA Wise competes in 13 intercollegiate varsity sports: Men's sports include baseball, basketball, cross country, football, golf and tennis; while women's sports include basketball, cross country, golf, lacrosse, softball, tennis and volleyball.

On April 23, 2012, the college was accepted as a provisional member of the Great Midwest Athletic Conference (G-MAC) and announced it would begin competition as the G-MAC's seventh full member in the 2013–2014 academic year.

[2] UVA Wise also announced it planned to submit the NCAA application prior to June 1, 2012.