He played college football at Purdue and was selected by the Jaguars in the fifth round of the 2007 NFL draft.

[2] Nwaneri attended Naaman Forest High School in Garland, Texas, where he was teammates with Melvin Bullitt.

[4] Nwaneri saw limited action as a rookie during the Jaguars' 2007 playoff run, playing in 9 games with 1 start.

The next season, he was elevated to starter after an injury to starting guard Vince Manuwai.

Nwaneri's most notable plays occurred in the 2011 season when he made two offensive fumble recoveries in separate games against the Carolina Panthers and the Baltimore Ravens.