The first Uddingston station, on the east side of the Glasgow Road bridge,[2] was opened by the Clydesdale Junction Railway on 1 June 1849.

Around 2005, ScotRail, SPT and South Lanarkshire Council funded[citation needed] improvements that included: Since 2005, a volunteer group has been responsible for beautifying the station precinct with flower beds and hanging baskets.

[12] 1867: On a westbound collision with the arch of the Glasgow Road bridge, a transported van rolled back into the following carriage, injuring five passengers, two seriously.

[17] 1902: During fog, a passing engine inflicted massive head injuries to a man by the Haughhead Colliery signal box, about three-quarters mile (1.2 km) to the west.

After the front coupling hooked the mangled body, his clothing and limbs became scattered from the colliery signal box to Bellshill.

A brake failure caused the van to soon roll onto the main line, where it pursued and smashed into the rear of the train, which had inadvertently stopped 100 yards (91 m) west of Uddingston station.

[23] 1911: Near the Viewpark Colliery signal box, immediately east of Uddingston Junction, a westbound passenger train ran down two surfacemen.

[35] A goods yard existed to the north east of Glasgow Rd[citation needed] that included the siding for John Gray & Co.'s Uddingston Iron Works.

[36] The Viewpark Colliery siding, that stretched 600 yards (549 m) west-northwest, and slightly more east-southeast, from near the present day southern end of Spindlehowe Rd, was accessed initially from that location (just east of the Uddingston Junction),[4] and later from the NBR.