Together with Gene Myers he developed the suffix array, a data structure for string matching.

[9] In February 2015, Manber announced that he was leaving YouTube for the National Institutes of Health.

In February 2017, Manber went to work for the Department of Medicine at the University of California, San Francisco and a technical advisor to UCSF's Institute for Computational Health Sciences.

[citation needed] In October 2018, it was reported that Manber was joining Anthem as its chief AI officer.

[11] Manber served on the board of directors for Twiggle[12] and is an advisor to Amino Health.