The island within Oberuckersee was the residence of a Slavic ruler in the 10th century, and connected to the coast of the lake by a long wooden bridge.

On the northern end of Unteruckersee the city of Prenzlau is situated, nowadays the district capital of Uckermark.

In Middle Ages, it was granted urban rights by the Pomeranian Griffins earlier than Szczecin in 1234, shortly before they lost the Uckermark to the Margraviate of Brandenburg in 1250.

An effort of the von Arnim family to prepare it for large river boats ceased after a few decades in the 19th century.

In Ueckermünde, the Uecker ends in Szczecin Lagoon, which is connected to the Baltic Sea by the three straits Peenestrom, Świna and Dziwna.