[1] The most common presentation is a palsy of the deep motor branch of the ulnar nerve causing weakness of the interosseous muscles.

[2] Long distance bicycle rides are associated with transient alterations in ulnar nerve function.

Thus, Guyon's canal can be separated into three zones based on which portion of the ulnar nerve are involved.

Palsy of the ulnar motor nerve isolated to the wrist is treated with operative decompression, often with concomitant ganglion excision.

The surgery is to divide the volar carpal ligament which forms the roof of Guyon's canal, thereby reducing compression on the ulnar nerve.