The series continued the adventures of the Ultimates, including Nick Fury, Thor and Iron Man.

The first story arc, "The Republic is Burning",[2] takes place at the same as Hickman's other miniseries Ultimate Comics Hawkeye.

The first story arc by Jonathan Hickman had the emergence of two new superhuman threats, The People in the Southeast Asian Republic led by the brothers Xorn and Zorn, and the children of Tomorrow, led by Reed Richards.

in pieces, the last story arc which began with Jonathan Hickman as writer but ended with Sam Humphries as his replacement, had the Ultimates victorious and Reed Richards arrested for his crimes.

"[8] When further commenting on the current state of Ultimate Comics line, Joshua Yehl of IGN stated, "the direction of Ultimate Comics X-Men is curious, while Spider-Man's is a steady stream of solid issues, but Ultimates has risen to a place where the best elements of sci-fi and super heroes have combined into an unforgettable tale".