It was written by Lost co-creator Damon Lindelof, and illustrated by artist Leinil Francis Yu and colorist Dave McCaig.

The title characters square off after Wolverine is contracted by Nick Fury to assassinate the Hulk, who is known to be residing in Tibet.

He recounts meeting Nick Fury, Betty Ross and Jennifer Walters, and being told that the Hulk is alive and responsible for several "incidents" of mass destruction after a public "execution" by S.H.I.E.L.D.

(In the 2nd issue this line is delivered from another perspective as "Hello Bruce") We see the events leading up to the fight between Hulk and Wolverine from Banner's point of view.

The comic begins with Banner being left for dead on an off-shore ship, tied down to the deck with a bomb sitting beside him.

The Hulk swims to Omaha Beach, Normandy, France, transforming back into Banner as he reaches the shore.

Banner finds himself drifting from one location to the next, forced to relocate every time he loses control of his temper and becomes the Hulk.

The first time, a Parisian psychologist accuses Bruce of not letting himself get angry over losing Betty, calling him impotent and driving him over the edge.

The second time he is working as a farm hand and his boss mocks him for eating tofurkey, a tofu turkey substitute.

We then move forward to the point in which the first issue ended, where Logan says 'Hello Bruce', the first time we see the Hulk in the Ultimate Universe in a calm, rational state.

At the top of the mountain, Hulk is waiting and ready to eat one of Wolverine's legs, but before that happens a new arrival is airdropped onto the mountaintop, Ultimate She-Hulk.

Save for the last two pages, the issue consists of advancing flashbacks from the perspective of Betty Ross, including Bruce's attempted phone call and Wolverine's meeting with Fury, jumping to three days prior when Betty unsuccessfully attempts to convince Tony Stark and Steve Rogers to save Bruce from Logan.

Logan initially claims he blacked out after the Hulk tore him in half, instead of admitting he was awake for Bruce and Betty's sexual encounter.

At a panel at San Diego Comic-Con in 2008, Quesada and Lindelof announced that all of the remaining issues had been scripted, with Lindelof handing Quesada the final script in front of the audience, and that once Yu had finished his work on Secret Invasion, he would provide artwork for the remaining issues.

Quesada also wrote in his blog that Leinil Francis Yu was excited to get started on the series again, after Secret Invasion.

On September 10, 2013, the series was adapted into a Marvel Knights animated motion comic and released on DVD by Shout!