Umbrail Pass (in Italian: Giogo di Santa Maria) is a high mountain pass on the Italy–Switzerland border, connecting Santa Maria in Val Müstair with Bormio in the Adda valley.

On the Italian side, it connects to the Stelvio Pass road and the Valtellina.

The pass is named after the "Piz Umbrail", a nearby mountain peak.

The last unpaved section was a 1.5 km stretch on the Swiss side, running between elevations of 1,883 and 2,012 metres (6,178 and 6,601 ft).

During the 2017 Giro d'Italia, Umbrail Pass was reached during the stage from Rovetta to Bormio.