[7] In addition, the ability to learn associations through trial and error, such as the pairing of a name with a face, correlates with uncinate fasciculus microstructure.

[8] This relates to early work showing that surgical damage to the uncinate fasciculus is reliably associated with deficits in proper name retrieval.

[4] Future researchers should focus on using superior diffusion imaging methods as well correlating specific symptoms, rather than presence or absence of disease state, with changes in white matter.

[16][17][18] Interestingly, Phineas Gage, a railroad worker who had an iron bar go through his left frontal lobe [19] also sustained damage to the uncinate fasciculus.

After the accident, his personality was radically transformed, becoming impulsive, making poor decisions, and failing to follow social norms and conventions.

Last, consistent abnormalities in the uncinate fasciculus are found in Alzheimer's disease, semantic dementia, and temporal lobe epilepsy.