An anime television series adaptation produced by Atelier Pontdarc aired from July 2022 to March 2023.

In modern-day Japan, Takafumi Takaoka picks up his uncle who recently awakened from a 17-year coma after being hit by a truck.

[48] Christopher Farris of Anime News Network reviewed the manga's first volume in 2021, critiquing that despite "a few good high-concept observations" and some subversive deadpan humor, he felt it didn't have anything else to say beyond that and was critical of Hotondoshindeiru's art style being made up of "rough and minimally expressive" character models and amateurishly rendered backgrounds, saying "Like so many other aside Isekai projects, Uncle From Another World has the makings of an entertaining concept, but thus far hasn't fully delivered as a complete story.

"[49] Fellow ANN editor Richard Eisenbeis placed Uncle from Another World at number four on his top 5 best anime list of 2022, praising its "non-stop riot of fish-out-of-water humor" and "stellar supporting cast".

[50] Allen Moody, writing for THEM Anime Reviews, said: "The show's uneven and chaotic, but so's its protagonist, so I guess it fits.

Not all the moments are gems, and it starts a little slowly (until Uncle's "memories" kick in), but its curmudgeonly protagonist makes this at least an interesting variant on what is otherwise a tiresomely cliched genre.