[1] The U.S. Army Medical Research Institute of Chemical Defense (USAMRICD), at Aberdeen Proving Ground, Maryland, continues to operate.
[4] The United States began large-scale production of an improved vesicant gas known as Lewisite, for use in an offensive planned for early 1919.
[5][6] After the war, the U.S. was party to the Washington Arms Conference Treaty of 1922 which would have banned chemical weapons but failed because it was rejected by France.
At least one accident occurred: On the night of December 2, 1943, German Junkers Ju 88 bombers attacked the port of Bari in Southern Italy, sinking several American ships – among them John Harvey, which was carrying mustard gas.
[7] The US military conducted experiments with chemical weapons like lewisite and mustard gas on Japanese American, Puerto Rican and African Americans in the US military in World War II to see how non-white races would react to being mustard gassed, with Rollin Edwards describing it as "It felt like you were on fire, Guys started screaming and hollering and trying to break out.
Thousands of American soldiers were exposed to chemical warfare agents during Cold War testing programs (see Edgewood Arsenal human experiments), as well as in accidents.
[9] The U.S. also investigated a wide range of possible nonlethal, psychobehavioral chemical incapacitating agents including psychedelic indoles such as lysergic acid diethylamide (also experimenting to see if it could be used for effective mind control) and marijuana derivatives, certain tranquilizers like ketamine or fentanyl, as well as several glycolate anticholinergics.
[12] The growing protests over the U.S. role in the Vietnam War, the use of defoliants there, and the use of riot control agents both in Southeast Asia and inside the U.S. (as well as heightened concern for the environment) all gradually increased public hostility in the U.S. toward chemical weapons in the 1960s.
Three events particularly galvanized public attention: a 1968 sheep-kill incident at Dugway Proving Ground, Operation Cut Holes and Sink ‘Em (CHASE) — a program involving disposal of unwanted munitions at sea — and a 1969 accident with sarin at Okinawa.
The U.S. began to research safer disposal methods for chemical weapons in the 1970s, destroying several thousand tons of mustard gas by incineration at Rocky Mountain Arsenal and nearly 4,200 tons of nerve agent by chemical neutralization at Tooele Army Depot and Rocky Mountain Arsenal.
The U.S. began stockpile reductions in the 1980s, removing some outdated munitions and destroying its entire stock of BZ beginning in 1988.
In 1986, President Ronald Reagan made an agreement with Chancellor Helmut Kohl to remove the U.S. stockpile of chemical weapons from Germany.
As part of Operation Steel Box, in July 1990, two ships were loaded with over 100,000 shells containing GB and VX taken from U.S. Army weapons storage depots such as Miesau and then-classified ammunition FSTS (forward storage/transportation sites) and transported from Bremerhaven, Germany, to Johnston Atoll in the Pacific, a 46-day nonstop journey.
[17] Beginning in 1999, ACWA was tasked by the Secretary of Defense to demonstrate six incineration alternatives to destroy the remaining U.S. chemical weapons stockpile stored at the Blue Grass Army Depot in Kentucky and the U.S. Army Pueblo Chemical Depot in Colorado, the final two stockpiles in the United States.
The United States and Russia possess the largest remaining chemical stockpiles among Convention members according to the Centre for Arms Control and Non-proliferation, as of 2014.
The stockpiles were maintained in exclusion zones[22] at the following Department of Army installations (the percentages shown are reflections of amount by weight): The remaining 6.6% was located on Johnston Atoll in the Pacific Ocean.
[18] The U.S. disposed of the more dangerous modern chemical weapons before starting the destruction of its older mustard gas stockpile which presented additional difficulties due to the poor condition of some of the shells.
[24] The original commitment in Phase III required all countries to have 45 percent of the chemical stockpiles destroyed by April 2004.
[27] These two facilities held 10.25% of the U.S. 1997 declared stockpile and destruction operations are under the Program Executive Office, Assembled Chemical Weapons Alternatives.
In 1988–1990, the destruction of munitions containing BZ, a non-lethal hallucinating agent occurred at Pine Bluff Chemical Activity in Arkansas.